Evidence map›Paper›PMID 42412112›Full record

ArticleCancer immunology, immunotherapy : CII2026

CXCL13-CXCR5 signaling in CD8

Daniel D Shapiro, Kye D Nichols, Moon Hee Lee, Pavlos Msaouel, Yuanshan Li, Yang Zong, Rong Hu, Wei Huang, Karla Esbona, Toshi Kinoshita and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Daniel D ShapiroDepartment of Urology School of Medicine and Public Health, University of Wisconsin, 1685 Highland Avenue, Madison, WI, 53705, USA. DDShapiro@wisc.edu.
Kye D NicholsDepartment of Urology School of Medicine and Public Health, University of Wisconsin, 1685 Highland Avenue, Madison, WI, 53705, USA.
Moon Hee LeeDepartment of Urology School of Medicine and Public Health, University of Wisconsin, 1685 Highland Avenue, Madison, WI, 53705, USA.
Pavlos MsaouelDepartment of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yuanshan LiDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Yang ZongDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Rong HuDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Wei HuangDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Karla EsbonaDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Toshi KinoshitaDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Paz LotanDepartment of Urology School of Medicine and Public Health, University of Wisconsin, 1685 Highland Avenue, Madison, WI, 53705, USA.
Daniel F RoadmanDepartment of Urology School of Medicine and Public Health, University of Wisconsin, 1685 Highland Avenue, Madison, WI, 53705, USA.
Everlyne NkadoriDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Stephanie M McGregorCarbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
David J BeebeDepartment of Pathology and Laboratory Medicine School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Sheena C KerrDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Christian M CapitiniCarbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Edwin Jason AbelDepartment of Urology School of Medicine and Public Health, University of Wisconsin, 1685 Highland Avenue, Madison, WI, 53705, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520NIH HHS P30CA014520U.S. Department of Defense HT94252510612
6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) exhibits heterogeneity in immune infiltration and clinical outcomes, but the mechanisms governing recruitment and organization of tumor-reactive CD8

Indexed as

Carcinoma, Renal CellCD8-Positive T-LymphocytesChemokine CXCL13Kidney NeoplasmsReceptors, CXCR5AnimalsCell MovementHumansLymphocytes, Tumor-InfiltratingMiceSignal TransductionTumor MicroenvironmentChemokine CXCL13CXCL13 protein, humanCXCR5 protein, humanReceptors, CXCR5CD8 T cellChemokineCXCL13CXCR5Immune microenvironmentKidney cancerRenal cell carcinomaTumor microenvironment

Identifiers

PMID42412112

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.