Evidence map›Paper›PMID 42412605›Full record

ArticleJournal of chemical information and modeling2026

Machine Learning-Driven Discovery of Indole/Oxoindole-Piperazine Scaffolds as Dual MAO-B/Sig-1R Ligands for Neurodegenerative Disorders.

Ulisses Candido da Silva, Miller Santos Ferreira, Eduardo Borba Alves, Valéria Vieira Moura Paixão, Igor Rodrigues Lapa, Micaela M Barbosa Nogueira, Ricardo Pereira Rodrigues, Wanda Pereira Almeida, Marisi Gomes Soares, Daniela A Chagas-Paula and 3 more

Abstract read
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In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ulisses Candido da SilvaInstitute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais37130-00, Brazil.
Miller Santos FerreiraInstitute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais37130-00, Brazil.ORCID 0000-0002-9723-0528
Eduardo Borba AlvesDepartment of Pharmacy, Federal University of Sergipe (UFS), São Cristóvão, Sergipe49107-230, Brazil.
Valéria Vieira Moura PaixãoDepartment of Pharmacy, Federal University of Sergipe (UFS), São Cristóvão, Sergipe49107-230, Brazil.
Igor Rodrigues LapaInstitute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais37130-00, Brazil.
Micaela M Barbosa NogueiraInstitute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais37130-00, Brazil.
Ricardo Pereira RodriguesSchool of Pharmaceutical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo13083-871, Brazil.
Wanda Pereira AlmeidaSchool of Pharmaceutical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo13083-871, Brazil.
Marisi Gomes SoaresInstitute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais37130-00, Brazil.
Daniela A Chagas-PaulaDepartment of Chemistry, Federal University of Juiz de Fora, Juizde Fora, Minas Gerais36036-900, Brazil.
Albert Katchborian-NetoDepartment of Chemistry, Federal University of São Carlos (UFSCAR), São Carlos, São Paulo13565-905, Brazil.
Tiago Branquinho OliveiraDepartment of Pharmacy, Federal University of Sergipe (UFS), São Cristóvão, Sergipe49107-230, Brazil.
Danielle Ferreira DiasInstitute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, Minas Gerais37130-00, Brazil.ORCID 0000-0001-9129-4734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The monoamine oxidase B (MAO-B) enzyme and Sigma-1 (Sig-1R) receptor are therapeutically relevant targets implicated in neurodegenerative and neuropsychiatric disorders. Dual modulation of these proteins represents an attractive multitarget strategy for central nervous system drug discovery. In this study, we focused on indole/oxindole-based scaffolds, including indolamide and oxindole cores with piperazine motifs (often

Indexed as

Drug DiscoveryIndolesMachine LearningMonoamine OxidaseNeurodegenerative DiseasesPiperazinesReceptors, sigmaHumansLigandsMonoamine Oxidase InhibitorsQuantitative Structure-Activity RelationshipIndolesLigandsMonoamine OxidaseMonoamine Oxidase InhibitorsPiperazinesReceptors, sigma

Identifiers

PMID42412605
PMCPMC13417874

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.