Evidence map›Paper›PMID 42412927›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Endothelial Arf6 sustains electrical signaling and cerebral blood flow in mice through PIP

Maria F Noterman-Soulinthavong, María Sancho, Saúl Huerta de la Cruz, Michael Yarboro, Maurizio Mandalà, Masayo Koide, Nathalie Beaufort, Katalin Todorov-Völgyi, Emma Moreland, David Hill-Eubanks and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Maria F Noterman-SoulinthavongDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.ORCID 0000-0001-8524-2604
María SanchoDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.
Saúl Huerta de la CruzDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.
Michael YarboroDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.
Maurizio MandalàDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.
Masayo KoideDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.ORCID 0000-0002-1381-7074
Nathalie BeaufortDepartment of Translational Stroke and Dementia Research, Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-Universität, Munich 81377, Germany.
Katalin Todorov-VölgyiDepartment of Translational Stroke and Dementia Research, Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-Universität, Munich 81377, Germany.
Emma MorelandDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.
David Hill-EubanksDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.
Martin DichgansDepartment of Translational Stroke and Dementia Research, Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-Universität, Munich 81377, Germany.
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT 05405.ORCID 0000-0002-6608-8784

Funding

American Heart Association (AHA) 24POST1188081Deutsche Forschungsgemeinschaft (DFG) CRC 1744 (ID 548585053)Deutsche Forschungsgemeinschaft (DFG) DI 722/13-1Deutsche Forschungsgemeinschaft (DFG) DI 722/21-1Deutsche Forschungsgemeinschaft (DFG) Munich Cluster for Systems Neurology (EXC 2145 SyNergy - ID 390857198)ERA-Net NEURON (NEURON) MatriSVDsFondation Leducq (Leducq Foundation) 22CVD01 BRENDAHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R35-HL-140027HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01-NS-110656HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01-NS-119971HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01-NS140868HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RF1-NS-128963P4-medicine project DigiMed Bayern n/aStiftung zur Erforschung der Vaskulären Demenz (Vascular Dementia Research Foundation) n/aThe Spanish Ministry of Science and Innovation PID2023-147925OA-I00UVM | Totman Medical Research Trust, University of Vermont n/a
6 · The paper itself

Abstract

Brain capillaries sense neural activity and direct blood flow to active regions-a process termed neurovascular coupling that underlies activity-dependent increases in local perfusion (functional hyperemia). A key contributor to functional hyperemic responses is the capillary endothelial cell (cEC) inward rectifier K

Indexed as

ADP-Ribosylation FactorsCerebrovascular CirculationEndothelial CellsPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Inwardly RectifyingADP-Ribosylation Factor 6AnimalsMiceSignal TransductionADP-Ribosylation Factor 6ADP-Ribosylation FactorsArf6 protein, mouseKir2.1 channelPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Inwardly RectifyingADP-ribosylation factor 6cerebral blood flowendothelial cellsKir2.1 channelsphosphatidylinositol-4,5-bisphosphate

Identifiers

PMID42412927
PMCPMC13367840

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.