Green HPLC-PDA method for simultaneous determination of linagliptin and cefixime with pharmacokinetic application in rats.

Weam M Othman, Nehal F Farid, Nourah Z Al-Zoman, Ibrahim A Darwish, Samah S Saad, Fatma F Abdallah

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Weam M OthmanPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Misr University for Science and Technology, 6th October City, Egypt. weam.mahmoud@must.edu.eg.ORCID https://orcid.org/0009-0000-5821-1968

Nehal F FaridPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Nourah Z Al-ZomanDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia.

Ibrahim A DarwishDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia.

Samah S SaadPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Misr University for Science and Technology, 6th October City, Egypt.

Fatma F AbdallahPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many individuals with diabetes have compromised immune systems and reduced peripheral sensation, making them susceptible to infections. As a result, combination therapy involving antidiabetic drugs and antibiotics has become essential. A newly introduced combination of the antidiabetic drug linagliptin (LIN) and the third-generation cephalosporin antibiotic cefixime (CEF) has been recommended to combat infections in diabetic patients.To optimize therapeutic efficacy and minimize adverse effects associated with this combination therapy, a reliable analytical method was essential for pharmacokinetic analysis and therapeutic drug monitoring. This study present, for the first time, a green high-performance liquid chromatographic method with photodiode array detection (HPLC-PDA) for the simultaneous determination of LIN and CEF in plasma samples. Chromatographic separation was achieved using a Symmetry C

Indexed as

Anti-Bacterial AgentsCefiximeLinagliptinAnimalsChromatography, High Pressure LiquidHypoglycemic AgentsMaleRatsReproducibility of ResultsThird Generation CephalosporinsAnti-Bacterial AgentsCefiximeHypoglycemic AgentsLinagliptinThird Generation CephalosporinsCefiximeHigh performance liquid chromatographyLinagliptinPharmacokinetic studiesTherapeutic drug monitoringType-2 diabetes

Identifiers

PMID42414397

DOI10.1038/s41598-026-57925-0

PMCPMC13342621

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