Evidence map›Paper›PMID 42415018›Full record

ArticleCost effectiveness and resource allocation : C/E2026

Sample size, model stability, and the interpretation of adjusted effect estimates: correspondence on Moreira et al.

Alejandro Chapa-Rodriguez, Hafiz Sarwar, Shraddha Narechania

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Cost effectiveness and resource allocation : C/E, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alejandro Chapa-RodriguezDepartment of Pulmonary and Critical Care Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, USA. achapa-rodriguez@capefearvalley.com.ORCID https://orcid.org/0009-0006-8175-8703
Hafiz SarwarDepartment of Pulmonary and Critical Care Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, USA.ORCID http://orcid.org/0009-0008-6618-2405
Shraddha NarechaniaDepartment of Pulmonary and Critical Care Medicine, Cape Fear Valley Medical Center, Fayetteville, NC, USA.ORCID http://orcid.org/0000-0002-5611-5304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We comment on the recent retrospective cohort by Moreira and colleagues evaluating intracranial-compliance-guided mean arterial pressure management. The adjusted multivariable logistic regression in the published analysis includes ten estimated coefficients against 22 ICU deaths, producing an adjusted odds ratio reported with a confidence interval spanning more than two orders of magnitude. We outline why these features are consistent with model instability rather than a precise causal estimate, identify a corroborating signal within the same model, and raise two secondary questions about control selection and the headline cost figure. We support the authors' call for prospective evaluation while suggesting that the inferential claims of the present analysis warrant more cautious presentation.

Indexed as

Cost-consequence analysisEvents per variableIntracranial complianceLogistic regressionMethodological correspondenceNeurocritical careSample size

Identifiers

PMID42415018
PMCPMC13340106

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.