Trial reportBMC oral health2026
The effect of foraminal enlargement and irrigant activation technique on post-operative pain in necrotic teeth - a clinical study.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesPost-endodontic pain remains a significant clinical challenge, impacting patient quality of life despite meticulous treatment. Its multifactorial origins include procedural factors such as foraminal enlargement and irrigation techniques, as well as patient-specific variables. While advanced irrigation activation methods like passive ultrasonic irrigation (PUI) and the XP-Endo Finisher have been shown to improve canal disinfection, their effects on postoperative pain are not fully established. We aim to compare the influence of foraminal enlargement combined with different activation methods ultrasonic and XP-Endo Finisher on postoperative pain levels in necrotic, single-rooted teeth, to identify approaches that optimize patient comfort.
methodsWe conducted a randomized, single-blind, four-arm clinical trial involving 60 patients with necrotic, asymptomatic single-rooted teeth exhibiting periapical lesions. Participants were randomly assigned to four groups: (1) foraminal enlargement with passive ultrasonic irrigation, (2) foraminal enlargement with XP-Endo Finisher activation, (3) no foraminal enlargement with passive ultrasonic irrigation, and (4) no foraminal enlargement with XP-Endo Finisher activation. Standardized root canal preparation, irrigation protocols, and obturation techniques were employed across all groups. Postoperative pain was self-recorded by patients using a visual analog scale (VAS) at 8 h, 24 h, 48 h, 3 days, and 1 week post-treatment. Data were analyzed using non-parametric statistical tests to compare pain levels among groups.
resultsAnalysis revealed no statistically significant differences in postoperative pain levels between the four groups at any assessed time point. Pain peaked within the first 8 h and gradually decreased over the week across all groups. The mean pain scores showed similar temporal patterns regardless of foraminal enlargement or activation technique used. The overall trend indicated that neither foraminal enlargement nor the specific irrigation activation methods significantly influenced postoperative discomfort in the studied sample.
conclusionsOur findings suggest that, in single-rooted necrotic teeth with periapical lesions, foraminal enlargement and the application of advanced irrigation activation techniques passive ultrasonic and XP-Endo Finisher do not significantly affect postoperative pain levels. These procedures can be incorporated into endodontic protocols without increasing patient discomfort when performed within standardized guidelines. The results underscore the importance of proper technique and disinfection strategies in achieving effective treatment outcomes while maintaining patient comfort. Further research with larger, more diverse populations and extended follow-up is warranted to confirm these findings and explore long-term effects.
trial registrationThe trial was registered on February 6, 2020, under the number (UDDS-284-21012020/SRC-1450).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.