Evidence map›Paper›PMID 42415079›Full record

ArticleBMC biology2026

Genetic divergence in Aedes aegypti mosquitoes potentially associated with enhanced capacity for arbovirus transmission.

Xiaodi Wang, Jovana Bozic, Brian B Tarimo, Tanise M S Stenn, Miles T McCollum, Juliana Carrillo, Eva A Buckner, Vincent O Nyasembe, Billy Ngasala, Rhoel R Dinglasan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaodi WangFlorida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA. xzw0039@uw.edu.
Jovana BozicFlorida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.
Brian B TarimoEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute-Bagamoyo Branch, Kingani Area, Bagamoyo, Coast, Tanzania.
Tanise M S StennFlorida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.
Miles T McCollumFlorida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.
Juliana CarrilloSoutheastern Center of Excellence in Vector Borne Diseases, Gainesville, FL, USA.
Eva A BucknerFlorida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.
Vincent O NyasembeDepartment of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Billy NgasalaDepartment of Parasitology and Medical Entomology, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Rhoel R DinglasanSoutheastern Center of Excellence in Vector Borne Diseases, Gainesville, FL, USA.
Travis C CollierIndependent Researcher, Vero Beach, FL, USA.
Eric P CaragataFlorida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.
Yoosook Lee *Florida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.
Derrick K Mathias *Florida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA. medvetent@gmail.com.

Funding

CDC HHS U01CK00510Emerging Pathogens Institute, University of Florida EPI 18-3National Institute of Food and Agriculture Hatch project FLA-FME-005889National Institute of Food and Agriculture Multistate Hatch project 1025565Southern IPM Center S22-027USDA National Institute of Food and Agriculture Crop Protection and Pest Management Regional Coordination Program 2018-70006-28884
6 · The paper itself

Abstract

backgroundAedes aegypti is the most important mosquito vector of arboviruses worldwide, originating on islands of the southwest Indian Ocean before spreading to Africa and, more recently, the Americas and Asia. Migration out of Africa was enabled by the evolution of behaviors that increased human-vector contact, and as Ae. aegypti became more domesticated, arboviral competence may have also increased. Here we investigate variation in vector competence between present-day populations of Ae. aegypti from Florida (USA) and Tanzania (East Africa) and use a genomics approach to examine genetic differentiation potentially underlying traits important for arbovirus transmission.

resultsUsing vector-competence experiments with dengue virus serotype 2, we demonstrate greater susceptibility to infection in American mosquitoes, along with higher viral loads and a shorter time to virus dissemination. We then sought to identify highly divergent genes potentially underlying these differences and discovered more than 1.6 million single nucleotide polymorphisms via exome sequencing. Of these, 1058 were highly differentiated between populations (F

conclusionsThis work offers insights into phenotypic variation and evolutionary divergence within Ae. aegypti, including naturally occurring genetic variants that may influence transmission-related characters.

Indexed as

AedesArbovirusesGenetic VariationMosquito VectorsAnimalsDengue VirusFloridaPolymorphism, Single NucleotideTanzaniaAedes aegyptiArbovirusDengueEvolutionMosquitoSynanthropyTransmissionVector competenceVectorial capacity

Identifiers

PMID42415079
PMCPMC13343669

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.