Evidence map›Paper›PMID 42415095›Full record

ArticleJournal of neuroinflammation2026

Forkhead box versus NF-κB hippocampal snRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis.

Karen M J van Loo, Daniel S Galvis-Montes, Annika Breuer, Juliane L Berns, Chiara A Hummel, Tobias Baumgartner, Moritz Freyberg, Katharina M Mair, Jan Bauer, Theodor Rüber and 8 more

Abstract read
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Karen M J van Loo *Department of Epileptology, Neurology, RWTH Aachen University, Aachen, Germany.
Daniel S Galvis-Montes *Department of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Annika BreuerDepartment of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Juliane L BernsDepartment of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Chiara A HummelDepartment of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Tobias BaumgartnerDepartment of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Moritz FreybergDepartment of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Katharina M MairDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, Austria.
Jan BauerDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, Austria.
Theodor RüberDepartment of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Ashley J van Waardenbergi-Synapse, Cairns, Australia.
Motaz HamedClinic for Neurosurgery, University Hospital Bonn, Bonn, Germany.
Valeri BorgerClinic for Neurosurgery, University Hospital Bonn, Bonn, Germany.
Hartmut VatterClinic for Neurosurgery, University Hospital Bonn, Bonn, Germany.
Rainer SurgesDepartment of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany.
Susanne SchochInstitute of Cellular Neurosciences II, University Hospital Bonn, Bonn, Germany.
Albert J Becker *Institute of Cellular Neurosciences II, University Hospital Bonn, Bonn, Germany.
Julika Pitsch *Department of Epileptology, University Hospital Bonn, Venusberg-Campus 1, Bonn, D-53127, Germany. jpitsch@uni-bonn.de.ORCID http://orcid.org/0000-0002-6688-4916

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesAutoantibodies (ABs) against intracellular proteins, including glutamate-decarboxylase 65 (anti-GAD65), are increasingly recognized in autoimmune and limbic encephalitis (AE/LE). Anti-GAD65 LE frequently progresses to severe temporal lobe epilepsy (TLE), neuropathologically characterized by hippocampal sclerosis (HS) and variable infiltration of cytotoxic T lymphocytes (CTLs). Recently, we have identified Drebrin (DBN) as a new intracellular target protein of ABs in index patients with suspected AE. Here, we aim to characterize key molecular and cellular signatures of hippocampal tissue from anti-GAD65- (GAD65-TLE) versus anti-DBN-positive TLE (DBN-TLE) patients correlated to clinical parameters.

methodsWe examined hippocampal neuropathology and performed exploratory single-nucleus RNA sequencing (snRNA-seq) of hippocampal tissue from DBN- and GAD65-TLE patients, integrated with key clinical data from a large patient cohort.

resultsAlthough the hippocampi of the two patient groups were neuropathologically virtually indistinguishable, exploratory snRNA-seq revealed distinct transcriptional programs. DBN-TLE patients (n = 2) showed transcriptional signatures enriched for forkhead box (Fox) transcription factor family, whereas GAD65-TLE patients (n = 2) displayed transcriptional signatures enriched for transcripts related to NF-κB- signaling. In a larger cohort, DBN-TLE patients (n = 22) showed significantly more favorable pharmacological responsiveness than GAD65-TLE patients (n = 35), who were largely pharmacoresistant. Notably, in a T cell-mediated mouse model for LE, similar inflammatory programs were dynamically regulated.

conclusionThese findings provide a discovery-based transcriptomic signatures of rare autoimmune hippocampal tissue, revealing distinct immune-associated transcriptional states in anti-DBN- versus anti-GAD65-positive AE/TLE patients despite virtually indistinguishable hippocampal pathology in both groups and support further investigations of disease-specific therapeutic strategies.

Indexed as

AutoantibodiesEncephalitisForkhead Transcription FactorsGlutamate DecarboxylaseHippocampusLimbic EncephalitisNF-kappa BAdultAnimalsEpilepsy, Temporal LobeFemaleHippocampal SclerosisHumansMaleMiceMiddle AgedAutoantibodiesForkhead Transcription FactorsGlutamate Decarboxylaseglutamate decarboxylase 2NF-kappa BAutoimmune encephalitisDrebrinFoxO signaling pathwayGlutamate decarboxylase 65 (GAD65)Temporal lobe epilepsy

Identifiers

PMID42415095
PMCPMC13343577

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.