Evidence map›Paper›PMID 42415119›Full record

ArticleNutrition & metabolism2026

Artificial sweetener intake and risk of chronic obstructive pulmonary disease: a mediation analysis based on plasma metabolic biomarkers.

Miaomiao Fan, Yan Chen, Xiaolin Yin, Shasha Zhao, Jian Feng, Zhaoping Li, Qihui Zhang, Chen Jiang, Hao Bai, Liyong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Miaomiao Fan *Department of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China.
Yan Chen *Department of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China.
Xiaolin Yin *Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Shandong, Jinan, China.
Shasha Zhao *Department of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China.
Jian FengDepartment of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China.
Zhaoping LiDepartment of Clinical Nutrition, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, Jinan, China.
Qihui ZhangDepartment of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China.
Chen JiangDepartment of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China.
Hao BaiDepartment of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China. baihao1991@email.sdu.edu.cn.
Liyong ChenDepartment of Nutrition, Qilu Hospital of Shandong University, Shandong, Jinan, China. chenle73@email.sdu.edu.cn.

Funding

National Key Research and Development Program of China 2022YFF1100604
6 · The paper itself

Abstract

backgroundThe long-term respiratory health effects of artificial sweetener consumption remain unclear. This study aimed to investigate the associations of artificial sweetener intake with the risk of chronic obstructive pulmonary disease (COPD) and lung function, and to explore the potential mediating role of circulating metabolites.

methodsHabitual intake of artificial sweeteners (teaspoon/day) was assessed via multiple 24-h dietary recalls. The multivariate Cox proportional hazards regression was used to analyze the association between AS and risk of COPD, and linear regression was used to analyze associations with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV

resultsA total of 164,656 participants were included. Over a median follow-up of 14.88 years, 4132 incident COPD cases were identified. Compared with non-consumption, higher consumption of artificial sweeteners was associated with a 27% increased risk of COPD (HR = 1.27, 95% CI: 1.14, 1.40) and decreased lung function, including FVC (β: -39.48 mL, 95% CI: -56.53, -22.43, p < 0.001) and FEV

conclusionHigher intake of artificial sweeteners is associated with an elevated risk of COPD and impaired lung function. These associations are partially mediated through pathways related to lipoprotein metabolism and fatty acid profiles.

Indexed as

Artificial sweetenersChronic obstructive pulmonary diseaseMetabolic biomarkersUK Biobank

Identifiers

PMID42415119
PMCPMC13637212

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.