ReviewAdvanced healthcare materials2026
Hydrogel-Based Systems in Intrauterine Adhesions: Bridging the Gap from Bench to Bedside.
Review in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Intrauterine adhesions are a significant cause of female infertility, necessitating advanced therapeutic approaches beyond conventional surgery. Hydrogel-based systems have emerged as a promising strategy due to their unique biochemical and physical properties, which support endometrial regeneration and prevent adhesion recurrence. This review provides a focused overview of the composition, classification, and functional characteristics of hydrogels in intrauterine adhesion therapy. It also discusses recent advancements in hydrogel applications, highlighting their roles as both physical barriers and delivery platforms for drugs, cytokines, cells, and extracellular vesicles. Although certain hydrogels, particularly hyaluronic acid-based formulations, have demonstrated progress in clinical settings, significant challenges persist. These include the need for precise spatiotemporal control over therapeutic release, biodegradability aligned with tissue remodeling, and addressing long-term safety concerns. The review also summarizes innovative design strategies aimed at enhancing hydrogel functionality, such as stimuli-responsive, visualized, and 3D-printed hydrogels tailored for personalized treatments. In conclusion, this review emphasizes the importance of bridging laboratory innovations with clinical applicability through standardized manufacturing practices, robust preclinical models, and interdisciplinary collaboration. The ultimate goal is to fully harness the potential of hydrogels to restore uterine function, improve reproductive outcomes, and achieve live births.
Indexed as
Identifiers
42415487What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.