ReviewBioMed research international2026
Flavonoids and miRNA Modulation: A Novel Approach to Managing Cancer, Diabetes, Depression, and Neurological Disorders.
Review in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Flavonoids and miRNA Modulation: A Novel Approach to Managing Cancer, Diabetes, Depression, and Neurological Disorders.BioMed research international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
microRNAs (miRNAs) regulate gene expression post-transcriptionally and play essential roles in various cellular processes. Disruption of their normal expression contributes to the pathogenesis of numerous diseases, including cancer, diabetes, depression, and neurological disorders. Consequently, restoring or inhibiting miRNA function has become a major focus of research, utilizing advanced technologies. Despite their potential, the clinical application of these technologies remains limited due to challenges related to delivery, specificity, cost, and safety. In contrast, growing evidence suggests that natural compounds-particularly flavonoids, a class of polyphenolic compounds abundant in plant-based foods such as fruits, vegetables, tea, and whole grains-can beneficially modulate miRNA expression. Studies across various disease models have demonstrated that flavonoids influence disease-related pathways through miRNA regulation, showing promising results in reducing disease complications, especially in preclinical mouse models. Therefore, diets rich in flavonoids are not only beneficial for disease prevention but also hold potential therapeutic value through the targeted modulation of miRNAs. The effectiveness of flavonoids across a wide spectrum of chronic diseases introduces a novel class of miRNA modulators with significant potential for clinical application. This review comprehensively examines recent studies on the use of various flavonoids in cellular models, animal models, and human tissue samples related to cancer, diabetes, depression, and neurological disorders. It further explores the molecular mechanisms through which flavonoids regulate miRNA expression, including transcriptional control, epigenetic modifications, and modulation of signaling pathways. Additionally, the review discusses the therapeutic opportunities and challenges associated with flavonoid use and proposes potential strategies to overcome these limitations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.