ArticleClinical kidney journal2026
Urinary angiotensinogen as a novel mortality predictor in diabetic kidney disease: a propensity-matched analysis from the KNOW-CKD.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patients with diabetic kidney disease (DKD) face a substantially higher risk of premature death compared to nondiabetic counterparts, yet accurate biomarkers for stratifying this mortality risk beyond conventional kidney function measures are currently lacking. We investigated whether urinary angiotensinogen (UAGT), reflecting intrarenal renin-angiotensin-aldosterone system activity, predicts all-cause mortality differently among patients with Methods: This prospective cohort study included 824 propensity score-matched patients (412 with diabetes and 412 without diabetes) from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. Participants were categorized into quintiles by baseline urinary angiotensinogen-to-creatinine ratio (UAGT/Cr). Cox proportional hazards models estimated adjusted hazard ratios (HRs) for all-cause mortality. Results: During median follow-up of 8.9 years, 149 deaths occurred. In patients with diabetes, the highest UAGT/Cr quintile was independently associated with increased mortality compared to the reference quintile (adjusted HR 3.61, 95% confidence interval 1.67-7.81, Conclusion: UAGT/Cr independently predicts all-cause mortality specifically in CKD patients with diabetes but not in those without diabetes, suggesting its potential utility as an etiology-specific prognostic biomarker for risk stratification in DKD.
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