ArticleFrontiers in cardiovascular medicine2026
Mineralocorticoid receptors are implicated in the initial steps of the cardiorenal damage induced by ethanol.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oxidative stress is an early mediator of ethanol-induced cardiorenal injury and dysfunction. The enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a key role in the generation of reactive oxygen species (ROS) triggered by ethanol. In certain tissues, the pro-oxidative and pro-inflammatory effects of ethanol occur via activation of mineralocorticoid receptors (MR). We hypothesized that MR blockade would prevent the redox imbalance induced by ethanol during the early stages of cardiac and renal changes. Methods: Male Wistar Hannover rats were treated with ethanol for five weeks. The contribution of the MR pathway to the cardiorenal effects of ethanol were evaluated with potassium canrenoate, an antagonist of the MR (MRA). Results: Blockade of MR prevented the increase in lipoperoxidation and superoxide (O Conclusion: The MR pathway mediates pro-oxidative effects in the early stages of ethanol-induced cardiorenal dysfunction.
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