ArticleTransplantation direct2026
Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion.
Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ex vivo normothermic perfusion (EVNP) allows for comprehensive functional assessment; however, current scoring systems are validated only for short perfusion durations. This study investigates the utility of the EVNP quality assessment score for a 6-h period to predict viability in discarded human kidneys. Methods: Twenty human kidneys from marginal donors, previously declined for transplantation, underwent 6-h EVNP. Functional parameters (renal blood flow, resistance index, urine output), perfusate biochemistry, tissue injury biomarkers, and histology were assessed. Kidneys were stratified by EVNP score: group A (1-2), group B (3), and group C (4-5). Results: Group A demonstrated significantly higher renal blood flow (median 213.5 versus 145.1 [B] versus 81.7 mL/min [C], Conclusions: The EVNP score may assist in identifying kidneys with potential for transplantation despite suboptimal histology, which could contribute to reducing the underutilization of marginal grafts.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.