Evidence map›Paper›PMID 42416262›Full record

ArticleTransplantation direct2026

Attenuating Ischemia and Reperfusion Injury Using NAD

Bret Verhoven, Yao Tong, Peter Chlebeck, Weixiong Zhong, Weifeng Zeng, Heather Jennings, Brooke Miller, Grace Heise, Mia Levitsky, Ruosen Xie and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bret VerhovenDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Yao TongDepartment of Biomedical Engineering, University of Wisconsin Institute for Discovery, Madison, WI.
Peter ChlebeckDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Weixiong ZhongDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Weifeng ZengDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Heather JenningsDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Brooke MillerDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Grace HeiseDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Mia LevitskyDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Ruosen XieDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI.
Shaoqin GongDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI.
David P Al-AdraDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.ORCID https://orcid.org/0000-0002-4469-6375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ischemia and reperfusion (IR) injury is a major complication in solid organ transplantation, necessitating new therapeutic strategies to suppress IR injury and thereby reduce early allograft dysfunction and delayed graft function. In kidney transplantation, IR injury is associated with disruption of mitochondrial homeostasis, including depletion of nicotinamide adenine dinucleotide (NAD Methods: C57BL/6NCrl mice underwent a laparotomy and occlusion of the left renal pedicle for 30 min to induce IR injury. Right nephrectomy was performed during the injury incubation. Mice received the test agents by 2 different techniques: direct kidney injection via the renal artery and systemically via intravenous (IV) injection into the vena cava. Mice received a single dose of the NAD Results: A single dose of NAD Conclusions: These results justify further development of this novel NAD

Identifiers

PMID42416262
PMCPMC13340656

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.