ArticleFrontiers in sports and active living2026
Preliminary effects of a four-month circuit training intervention on cognitive function and exploratory plasma proteomic profiles in middle-aged and older women: an open-label randomized controlled trial.
Article in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Although exercise can help prevent age-related cognitive decline, the mechanisms underlying its effects on cognition, immune function remain unclear. Therefore, this study comprehensively examined the effects of circuit training on cognitive function, and the plasma proteome in middle-aged to older women. Methods: Forty-eight women were assigned to either a four-month circuit training program ( Results: Within-group changes in Stroop interference and d-prime were observed in the circuit training intervention group. Furthermore, the proteins significantly elevated in the exercise intervention group were functionally categorized into anti-inflammatory and immunosuppressive pathways (LRRC25, IL10RA), angiogenesis and tissue remodeling (PROK1, TNFRSF12A), and immune cell activation (CD7). However, no protein-cognition associations remained significant after FDR correction. Conclusions: This open-label randomized controlled trial provides preliminary evidence that a 4-month circuit training intervention may improve selected cognitive outcomes and alter circulating proteins related to immune, inflammatory, and carbohydrate-binding functions in middle-aged and older women. However, protein-cognition associations did not remain significant after FDR correction. These findings should be interpreted as hypothesis-generating and require confirmation in larger studies with integrated cognitive and molecular analyses.
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