Evidence map›Paper›PMID 42416402›Full record

ReviewExploration of targeted anti-tumor therapy2026

Why precision oncology works: lessons from gastrointestinal stromal tumours.

Si Ying Adelina Ho, Alwyn Hong Sheng Tok, Hui Qi Megan Kimberly Han, Jens Samol, Vishal G Shelat

Abstract readReview
In one paragraph

Review in Exploration of targeted anti-tumor therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Si Ying Adelina HoMinistry of Health Holdings, Singapore 139691, Singapore.ORCID https://orcid.org/0009-0009-6830-3730
Alwyn Hong Sheng TokYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Hui Qi Megan Kimberly HanYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Jens SamolDepartment of Medical Oncology, Tan Tock Seng Hospital, Singapore 308433, Singapore.ORCID https://orcid.org/0000-0001-6109-3528
Vishal G ShelatYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.ORCID https://orcid.org/0000-0003-3988-8142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal stromal tumours (GISTs) are the clearest solid-tumour model of precision oncology because diagnosis, prognosis, and treatment are strongly shaped by molecular genotype. The discovery of activating mutations in

Indexed as

GISTKIT mutationmolecular classificationPDGFRA mutationtargeted therapytreatment sequencingtyrosine kinase inhibitors

Identifiers

PMID42416402
PMCPMC13337571

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.