ArticleFrontiers in bioengineering and biotechnology2026
Experimental study on antler powder/chitosan/β-glycerophosphate/polyvinyl alcohol composite platelet-rich fibrin scaffold for repairing periodontal bone defects in rabbits.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study evaluated and compared the efficacy of five scaffold materials-AP (Antler Powder)/CS (Chitosan)/β-GP (β-Glycerophosphate)/PVA (Polyvinyl Alcohol) composite scaffold with Platelet-Rich Fibrin (PRF), the same scaffold without PRF, an AP/PVA scaffold, PRF gel alone, and Bio-Oss® bone powder-in repairing periodontal bone defects and promoting periodontal tissue regeneration. Methods: Fifty-four New Zealand White rabbits were randomly divided into six groups (n = 9/group). A unilateral periodontal bone defect model was established in each rabbit. The defects were treated as follows: (1) AP/CS/β-GP/PVA-PRF composite scaffold; (2) AP/CS/β-GP/PVA scaffold; (3) AP/PVA scaffold; (4) PRF gel; (5) Bio-Oss® (positive control); and (6) no implantation (blank control). Three rabbits per group were sacrificed at 4, 8, and 12 weeks postoperatively. Outcomes were assessed Results: Gross observation revealed normal gingival color, contour, and texture, with probing depths ≤1 mm in all implanted groups, including the Bio-Oss® group. In contrast, the blank control group exhibited reduced alveolar bone height and 2-3 mm of gingival recession by 8 weeks. Radiographic analysis at 4, 8, and 12 weeks demonstrated continuous bone regeneration in all implanted groups, which showed significantly superior repair outcomes compared to the blank control (P < 0.05). Histologically, all implanted groups displayed the formation of cementum-like tissue, periodontal ligament-like fibers, and alveolar bone-like tissue on the root surface, with progressive maturation over time. Statistical analysis (one-way ANOVA with Conclusion: The AP/CS/β-GP/PVA-PRF composite tissue-engineered scaffold significantly promotes periodontal tissue regeneration and bone mineralization in periodontal bone defects, which shows good clinical application potential for periodontal defect repair.
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