ArticleReviews in cardiovascular medicine2026
Early Cardiac Workload and Long-Term Prognosis After Intracerebral Hemorrhage: Insights from a Large Multicenter Cohort.
Article in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Acute intracerebral hemorrhage (ICH) often induces a hyperadrenergic response, resulting in a significantly increased cardiac workload. This study aimed to assess the relationship between early cardiac workload and long-term outcomes following ICH, utilizing the rate-pressure product (RPP) as a simple surrogate indicator. Methods: We conducted an analysis of data from a large multicenter, prospective cohort comprising 1364 ICH patients. Heart rate (HR) and systolic blood pressure (SBP) were recorded to calculate the RPP. Multivariable logistic regression and Cox proportional hazards models were used to evaluate the associations of RPP with unfavorable functional outcome (modified Rankin Scale score >3) and all-cause mortality at 90 days and 1 year, respectively. Results: Elevated RPP was independently associated with unfavorable functional outcomes and all-cause mortality at 90 days and 1 year (all Conclusions: Early cardiac workload, quantified by the RPP, is a potent independent predictor of long-term unfavorable functional outcome and all-cause mortality in patients with ICH.
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