ReviewReviews in cardiovascular medicine2026
Integrin Signaling Pathways in Aortic Aneurysm and Dissection.
Review in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aortic aneurysm (AA) and aortic dissection (AD) are life-threatening aortic diseases that primarily arise from medial degeneration. Ruptures are invariably associated with fatal outcomes; however, there are currently no clinically proven medications to prevent the progression of aortic aneurysm and dissection (AAD), and surgery remains the most effective approach to eliminating the high risk of aortic rupture. The dysfunction and depletion of vascular smooth muscle cells, along with inflammation and extracellular matrix (ECM) remodeling, are key mechanisms underlying AAD development. Integrins are heterodimeric transmembrane receptors that link the ECM to the cytoskeleton and transmit bidirectional cellular signals. Moreover, integrins maintain cell morphology and modulate numerous physiological and pathophysiological processes. Meanwhile, increasing evidence indicates that integrins play a vital role in AAD. This review outlines the basic biology of integrins, discusses the specific functions and mechanisms of integrins in AAD pathogenesis, and aims to identify reliable non-invasive biomarkers for acute AAD and potential targets to halt disease progression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.