ArticleJCPP advances2026
Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders.
Article in JCPP advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Editorial: Transdiagnostic approaches to child and adolescent mental health-Integrating development, dimensions, and mechanisms.JCPP advances · 2026Article
- Disorder-Specific Genetic Effects Drive the Associations Between Psychopathology and Cognitive Functioning.Biological psychiatry global open science · 2026Article
- How are children's perceptions of the home environment associated with a general psychopathology factor across childhood?Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Specificity of Polygenic Scores for Psychiatric Disorders Beyond Transdiagnostic Genetic Risk.JAMA network open · 2026Article
- Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.Biological psychiatry · 2026Article
- In the genetics of the beholder: gene-environment interplay for internalising and externalising behaviours using polygenic scores and adolescent perceptions of parenting.European child & adolescent psychiatry · 2025Article
- Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder-specific genetic architecture and patterns of comorbidity. Methods: We applied genomic structural equation modeling to genome-wide association study summary statistics from 11 major psychiatric disorders to isolate genetic effects shared across disorders (the genomic Results: After accounting for transdiagnostic effects, genetic associations between psychiatric disorders changed substantially, with many correlations attenuated and some showing marked shifts in magnitude and direction. Genetic correlations between psychiatric disorders and external biobehavioural traits showed greater specificity. Conclusion: Removing transdiagnostic effects provides a more nuanced view of the genetic architecture underlying psychiatric disorders and sharpens inference about genetic relationships between disorders and other comorbid traits. This may inform future work on psychiatric classification, prediction, and treatment research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.