Proficient pyrimidine-based heterocyclic chemistry in medicine: advances in synthesis, biological, and SAR studies: a review.

Basant Farag, Mohamed R Fouad, Sampath Chinnam, Aamer Saeed, Ghada G El-Bana, Sobhi M Gomha

Abstract readReview

In one paragraph

Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Diethylene Glycol-Linked Ring-Fused Bis-Azoles: Target-Oriented Synthesis, In Silico Screening, and Antitumor Activity.ChemMedChem · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Basant FaragDepartment of Chemistry, Faculty of Science, Zagazig University Zagazig 44519 Egypt basantfarag@zu.edu.eg.ORCID https://orcid.org/0000-0002-5513-9945

Mohamed R FouadDepartment of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University Aflaton St., El-Shatby Alexandria 21545 Egypt mohammed.riad@alexu.edu.eg.ORCID https://orcid.org/0000-0002-4102-5111

Sampath ChinnamDepartment of Chemistry, M.S. Ramaiah Institute of Technology (Autonoumous Institution, Affiliated to Visvesvaraya Technological University, Belgaum) Bengaluru Karnataka 560054 India sampathchinnam@gmail.com.ORCID https://orcid.org/0000-0002-5334-9076

Aamer SaeedDepartment of Chemistry, Quaid-i-Azam University Islamabad 45320 Pakistan asaeed@qau.edu.pk.ORCID https://orcid.org/0009-0003-9432-1445

Ghada G El-BanaDepartment of Chemistry, Faculty of Science, Mansoura University El-Gomhoria Street Mansoura 35516 Egypt ghadaelbana@mans.edu.eg.ORCID https://orcid.org/0000-0002-3766-8202

Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah Madinah 42351 Saudi Arabia smgomha@iu.edu.sa.ORCID https://orcid.org/0000-0002-7739-2837

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the most varied class of organic compounds, N-heterocycles-especially pyrimidine derivatives, which are found in many remarkable synthetic substances-have important chemical, biological, and industrial uses. This review sheds light on a number of techniques for building diverse fused pyrimidine scaffolds using N-heterocycle moieties as adaptable precursors. Recent studies demonstrate the promise of pyrimidine-based heterocyclic hybrids, particularly those with bicyclic (pyrido[2,3-

Identifiers

PMID42416722

DOI10.1039/d6ra04538c

PMCPMC13340781

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.