ReviewCureus2026
Association Between Intraoperative Electroencephalogram Burst Suppression and Postoperative Delirium in Non-cardiac Surgery: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative delirium is a common complication in older surgical patients. Intraoperative EEG burst suppression may predict its occurrence. This study aimed to evaluate the association between burst suppression and postoperative delirium exclusively in non-cardiac surgery through systematic review and meta-analysis. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic review was conducted using PubMed, Cochrane Library, and ScienceDirect. Eligible studies included adult non-cardiac surgical patients assessing EEG burst suppression and postoperative delirium. Risk of bias was evaluated using RoB 2, the Newcastle-Ottawa Scale, and the Joanna Briggs Institute tools. Meta-analysis employed a random-effects Mantel-Haenszel model, with narrative synthesis for studies lacking extractable data. Across the included studies, the incidence of postoperative delirium (POD) ranged from 8.9% to 26%. Meta-analysis demonstrated that intraoperative burst suppression was significantly associated with POD occurrence (OR: 1.73, 95% CI: 1.03-2.90; I² = 38%). Patients with POD had significantly longer burst-suppression duration (mean difference of 25.31 min; p < 0.00001; I² = 0%). The pooled adjusted analysis confirmed an independent association between burst suppression and POD (OR: 2.69, 95% CI: 1.90-3.81; I² = 31%). Individual studies supported a dose-dependent relationship between the duration of suppression and the risk of delirium. Anesthetic agents influenced the suppression burden - propofol was associated with longer durations, whereas desflurane was associated with increased POD risk, independent of suppression. Preoperative cognitive impairment and frailty were identified as significant effect modifiers, increasing susceptibility to burst suppression and subsequent delirium. Intraoperative EEG burst suppression is significantly associated with postoperative delirium in non-cardiac surgery. Duration and patient vulnerability influence risk, highlighting the potential of duration as a modifiable intraoperative predictor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.