ArticleCureus2026
Determinants of Cardiovascular Events After Simultaneous Pancreas Kidney Transplantation: A Retrospective Cohort Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background Simultaneous pancreas-kidney transplantation (SPK) provides important metabolic and renal benefits, but cardiovascular complications remain a source of post-transplant morbidity and mortality. Factors associated with major adverse cardiovascular events (MACE) in contemporary SPK populations remain incompletely characterized. Methods We performed a single-center retrospective cohort analysis of 80 adult SPK recipients transplanted between 2018 and 2025. The primary endpoint was post-transplant MACE, defined as a composite of nonfatal myocardial infarction, nonfatal stroke, cardiovascular death, heart failure hospitalization, or clinically significant arrhythmia. MACE was evaluated as a binary outcome. The multivariable logistic regression model included one-month estimated glomerular filtration rate (eGFR) and kidney cold ischemic time. Results MACE occurred in 14 recipients (17.5%). Compared with recipients without MACE, those with MACE had more frequent post-transplant insulin use (P=0.013), longer kidney cold ischemic time (P=0.015), and higher donor body mass index (P=0.001). The triglyceride-glucose index was not significantly associated with MACE. In multivariable analysis, higher one-month eGFR was associated with lower odds of MACE (adjusted odds ratio, 0.61 per 10 mL/min/1.73 m² increase; 95% confidence interval (CI), 0.38-0.97; P=0.040). Kidney cold ischemic time showed a borderline association with MACE (adjusted odds ratio per hour, 1.28; 95% CI, 1.00-1.67; P=0.057). Model discrimination was modest, with an area under the curve of 0.68. Conclusions Among SPK transplant recipients, lower early kidney allograft function was associated with higher observed odds of post-transplant cardiovascular events. The triglyceride-glucose (TyG) index was not independently associated with MACE. Because few events occurred, these findings should be interpreted as exploratory and validated in larger studies.
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