Evidence map›Paper›PMID 42417009›Full record

SynthesisPsychological medicine2026

Purpose in life and mortality: A meta-analysis of the published literature and individual-participant data of 488,765 participants followed for up to 32 years.

Angelina Sutin, Daisy Zavala, Elizabeth Milad, Yannick Stephan, Selin Karakose, Justin Brown, Antonio Terracciano, Martina Luchetti

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angelina SutinDepartment of Behavioral Sciences and Social Medicine, https://ror.org/05g3dte14Florida State University College of Medicine, Tallahassee, USA.ORCID 0000-0002-1824-8974
Daisy ZavalaDepartment of Behavioral Sciences and Social Medicine, https://ror.org/05g3dte14Florida State University College of Medicine, Tallahassee, USA.ORCID 0000-0002-9689-5616
Elizabeth MiladDepartment of Behavioral Sciences and Social Medicine, https://ror.org/05g3dte14Florida State University College of Medicine, Tallahassee, USA.ORCID 0000-0003-4111-2650
Yannick Stephanhttps://ror.org/051escj72University of Montpellier: Universite de Montpellier, France.
Selin KarakoseDepartment of Geriatrics, https://ror.org/05g3dte14Florida State University College of Medicine, Tallahassee, USA.ORCID 0000-0001-8629-4422
Justin BrownDepartment of Behavioral Sciences and Social Medicine, https://ror.org/05g3dte14Florida State University College of Medicine, Tallahassee, USA.ORCID 0000-0001-6732-1608
Antonio TerraccianoDepartment of Geriatrics, https://ror.org/05g3dte14Florida State University College of Medicine, Tallahassee, USA.ORCID 0000-0001-5799-8885
Martina LuchettiDepartment of Behavioral Sciences and Social Medicine, https://ror.org/05g3dte14Florida State University College of Medicine, Tallahassee, USA.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
The National Health and Trends StudyU01AG032947 · NIA · JOHNS HOPKINS UNIVERSITY · PI VICKI A. FREEDMAN, JENNIFER ANN SCHRACK · 2008 to 2026
$169.4M
Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Health, Wealth, and Wellbeing over the Life Course and Across GenerationsR01AG040213 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRIEDMAN, ESTHER M. · 2011 to 2025
$31.2M
WISCONSIN LONGITUDINAL STUDY--SIBLING INTERVIEWS (1)R01AG009775 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI HERD, PAMELA · 1991 to 2012
$23.4M
WORK, HEALTH, AND WELL-BEINGP01AG021079 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI PALLONI, ALBERTO B. · 2002 to 2011
$14.2M
Family Dynamics, Fertility, and Investments in Children Across Generations - Administrative SupplementR01HD069609 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Thomas Fraser Crossley · 2011 to 2026
$14.2M
Aging Together: Brothers and Sisters of the Wisconsin Longitudinal StudyR01AG033285 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI HERD, PAMELA, WARREN, JOHN ROBERT · 2009 to 2013
$11.8M
WIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009
$6.9M
NCATS NIH HHS UL1 TR000427NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR023942NIA NIH HHS HHSN271201300071CNIA NIH HHS P01 AG020166NIA NIH HHS P01 AG021079NIA NIH HHS R01 AG008523NIA NIH HHS R01 AG009775NIA NIH HHS R01 AG017644NIA NIH HHS R01 AG033285NIA NIH HHS R01 AG040213NIA NIH HHS R01 AG041868NIA NIH HHS R01 AG074573NIA NIH HHS R01AG074573NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG032947NICHD NIH HHS R01 HD069609
6 · The paper itself

Abstract

backgroundPurpose in life is consistently associated with better health outcomes, including lower risk of earlier mortality. We report an updated meta-analysis of the published literature, combined with analysis of individual-participant data, to address replicability, generalizability, and potential mechanisms of the association between purpose in life and risk of mortality.

methodsA random-effects meta-analysis of individual-participant data from ongoing longitudinal studies (

resultsPurpose in life was associated with a ~ 30% lower risk of earlier mortality (meta-analytic HR = .76 [1/.76 = 1.32], 95% CI = .70, .83). The association was apparent across sociodemographic groups, with some small differences in magnitude by age, race, and education. The association was attenuated but persisted, controlling for behavioral and clinical risk factors for mortality (meta-analytic HR = .85, 95% CI = .82, .89), or depression (meta-analytic HR = .91, 95% CI = .88, .94).

conclusionsA meta-analysis of 25 samples from the United States, Europe, and Asia indicated that purpose in life has a consistent association with lower risk of mortality. The association is due in part but not completely to behavioral, clinical, and psychological risk factors for earlier mortality.

Indexed as

MortalityHumansLongitudinal Studieslongevitymeaning in lifeIkigaimeta-analysispurpose in life

Identifiers

PMID42417009
PMCPMC13370182

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.