Evidence map›Paper›PMID 42417207›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Self-Propagating Acid Avalanche Unleashes Endogenous Iron to Fuel Potentiated Chemodynamic Therapy.

Dingshang Chen, Qingdeng Fan, Yingqian Zhou, Phocas Muragizi, Jiaoyang Zhu, Zongheng Li, Jieqiong Xie, Haobin Cai, Xinyu Chen, Lin Huang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dingshang ChenDepartment of Medical Imaging, The Third Affiliated Hospital, Southern Medical University (Academy of Orthopedics·Guangdong Province), Guangzhou, Guangdong, China.
Qingdeng FanSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Yingqian ZhouDepartment of Medical Imaging, The Third Affiliated Hospital, Southern Medical University (Academy of Orthopedics·Guangdong Province), Guangzhou, Guangdong, China.
Phocas MuragiziDepartment of Medical Imaging, The Third Affiliated Hospital, Southern Medical University (Academy of Orthopedics·Guangdong Province), Guangzhou, Guangdong, China.
Jiaoyang ZhuSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Zongheng LiSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Jieqiong XieResearch Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Haobin CaiSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Xinyu ChenSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Lin HuangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.
Zheyu ShenSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-0350-375X
Shipeng NingResearch Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Quan ZhouDepartment of Medical Imaging, The Third Affiliated Hospital, Southern Medical University (Academy of Orthopedics·Guangdong Province), Guangzhou, Guangdong, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2026A1515010589Guangdong Basic and Applied Basic Research Foundation 2414050003780Guangzhou Key Research and Development Program of China 2025B01J3007National Natural Science Foundation of China 32271374National Natural Science Foundation of China 32501164
6 · The paper itself

Abstract

The therapeutic efficacy of chemodynamic therapy (CDT) is intrinsically compromised by the mildly acidic tumor microenvironment (TME), which fails to satisfy the stringent pH demands required to mobilize endogenous iron for sustainable Fenton reactions. Herein, we propose a self-propagating "acid avalanche" strategy using CD44-targeting USGND@HMCS (i.e., ultrasmall gold nanodots-anchored hollow mesoporous copper sulfide) nanoreactors to hijack organelle homeostasis and unleash intracellular iron depots for catastrophic tumor destruction. Upon accumulation in TME, the nanoreactors degrade to release USGND, copper ions, and H

Indexed as

AcidsIronAnimalsCell Line, TumorCopperGoldHumansHydrogen-Ion ConcentrationHydrogen PeroxideTumor MicroenvironmentAcidsCopperGoldHydrogen PeroxideIronchemodynamic therapyendogenous ironH2Shollow mesoporous copper sulfidetriaxial acidification

Identifiers

PMID42417207
PMCPMC13509085

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.