Evidence map›Paper›PMID 42417481›Full record

ArticleCNS neuroscience & therapeutics2026

The Protective Mechanism of Continuous Theta Burst Stimulation in the Acute Phase of Stroke Through Modulation of the Calcineurin/AKT/FOXO1 Signaling Pathway.

Pengkun Yang, Haocheng Qin, Bao Zhou, Shenyi Kuang, Meixi Liu, Yi Wu, Peng Yuan, Kewei Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pengkun YangDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Haocheng QinDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-2723-4299
Bao ZhouDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0007-7774-9801
Shenyi KuangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Meixi LiuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-8790-682X
Yi WuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4955-3533
Peng YuanDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Kewei YuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Funding

National Key Research and Development Program of China 2023YFC3604801National Natural Science Foundation of China 82072547National Natural Science Foundation of China 82172544National Natural Science Foundation of China 82202799National Natural Science Foundation of China 82302865National Natural Science Foundation of China 82571927Shanghai Science and Technology Committee Sailing Program 23YF1403800
6 · The paper itself

Abstract

aimsTo investigate the neuroprotective effects of continuous theta-burst stimulation (cTBS) during the acute phase of ischemic stroke and its impact on neuronal apoptosis in the peri-infarct region.

methodsMCAO was induced in mice using the Longa method. cTBS was administered daily for seven days. Motor function and limb coordination were assessed behaviorally. Transcriptomic and proteomic analyses of the peri-infarct region were performed to explore mechanisms. Immunofluorescence and Western blot analyzed key proteins in the calcineurin/AKT/FOXO1 pathway, while TUNEL staining assessed neuronal apoptosis. AAV-mediated gene knockdown was used to validate the pathway's role in apoptosis.

resultscTBS improved motor performance, reduced infarct volume, and preserved peri-infarct tissue architecture. It suppressed calcineurin expression, enhanced calcineurin/AKT/FOXO1 pathway activation, and decreased neuronal apoptosis.

conclusioncTBS exerts neuroprotection by modulating the calcineurin/AKT/FOXO1 pathway, ultimately inhibiting neuronal apoptosis in the peri-infarct region.

Indexed as

CalcineurinForkhead Box Protein O1Proto-Oncogene Proteins c-aktSignal TransductionStrokeTranscranial Magnetic StimulationAnimalsApoptosisDisease Models, AnimalMaleMiceMice, Inbred C57BLCalcineurinForkhead Box Protein O1Foxo1 protein, mouseProto-Oncogene Proteins c-aktacute phaseAkt/FOXO1 signalingcontinuous theta burst stimulationextrinsic apoptosisischemic stroke

Identifiers

PMID42417481
PMCPMC13343732

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.