Evidence map›Paper›PMID 42417853›Full record

ArticleEuropean journal of nutrition2026

Dietary sialic acid intake and incident dementia: evidence from a large prospective cohort study.

Huiting Zheng, Haomin Yang, Hao Ma, Lin Zhu, Anping Liu, Xinhuang Hou, Changwei Yang, Weimin Ye

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Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Huiting Zheng *Department of Nutrition and Food Hygiene, School of Public Health, Fujian Medical University, Fuzhou, 350122, China.
Haomin Yang *Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, China.
Hao MaShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Beijing, China.
Lin ZhuDepartment of Nutrition and Food Hygiene, School of Public Health, Fujian Medical University, Fuzhou, 350122, China.
Anping LiuDepartment of Nutrition and Food Hygiene, School of Public Health, Fujian Medical University, Fuzhou, 350122, China.
Xinhuang HouDepartment of Vascular Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Changwei YangDepartment of Nutrition and Food Hygiene, School of Public Health, Fujian Medical University, Fuzhou, 350122, China. vivianyang87@fjmu.edu.cn.ORCID http://orcid.org/0000-0001-7931-8692
Weimin YeDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, China. ywm@fjmu.edu.cn.

Funding

National Major Science and Technology Projects of China 2022ZD0211600National Natural Science Foundation of China 82204023Research Start-up Fund of Fujian Medical University No.2023QH1065Research Start-up Fund of Fujian Medical University XRCZX2020019
6 · The paper itself

Abstract

purposeBeneficial effects of sialic acid on cognition have been most often seen in cognitive development in infant models, whereas the relevant evidence from ageing population studies remains limited. We aimed to investigate the associations of dietary sialic acids and their subtypes (Neu5Ac and Neu5Gc) with the incident dementia in a large prospective study.

methodsA total of 210,796 middle-aged and older participants from UK Biobank were included in this study. Dietary sialic acids intake was estimated using repeated 24-h dietary recall questionnaires. Cox proportional hazards models were used to evaluate the association of sialic acid and its subtypes with dementia risk.

resultsDuring a mean follow-up of 10.9 years, 2469 incident all-cause dementia were recorded, of which 1077 were Alzheimer's disease (AD), and 454 were vascular dementia (VaD). Compared with participants in the lowest quartile (median intake: 25.12 mg/d), participants in the third quartile of total sialic acids (median intake: 56.46 mg/d) were associated with a 18% lower risk of all-cause dementia (HR 0.82; 95% CI 0.73-0.92) and a 31% lower risk of VaD (HR 0.69; 95%CI 0.53-0.91), respectively. Similar associations were observed for Neu5Ac and Neu5Gc, respectively. After mutual adjustment, the association of Neu5Gc with all-cause dementia or VaD risk remained unchanged, whereas the association of Neu5Ac with dementia risk became non-significant after adjusting for Neu5Gc.

conclusionOur findings suggest a potential non-linear protective association between total sialic acid and risk of all-cause dementia and VaD.

Indexed as

DementiaDietN-Acetylneuraminic AcidAgedAlzheimer DiseaseDementia, VascularFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsUnited KingdomN-Acetylneuraminic AcidAlzheimer’s diseaseDementiaN-acetylneuraminic acidN-glycolylneuraminic acidSialic acidVascular dementia

Identifiers

PMID42417853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.