Evidence map›Paper›PMID 42418014›Full record

ArticleEuropean journal of nutrition2026

Plasma trimethylamine N-oxide and related metabolites and overall survival of high-grade serous ovarian cancer: a nested case-control study.

Meng-Meng Xie, Ya-Li Wang, Jia-Xin Liu, Xiao-Ying Li, Fang-Hua Liu, Wen-Rui Zheng, Wei-Yi Xing, Bang-Quan Liu, Lang Wu, Yue Han and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meng-Meng Xie *Department of Gynecology, Liaoning Institute of birth health and development, Reproductive Hospital of China Medical University, Shenyang, Liaoning, China.
Ya-Li Wang *Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Jia-Xin Liu *Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Xiao-Ying Li *Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Fang-Hua LiuDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Wen-Rui ZhengDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Wei-Yi XingDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Bang-Quan LiuKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, China.
Lang WuCancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.
Yue HanDepartment of Gynecology, Liaoning Institute of birth health and development, Reproductive Hospital of China Medical University, Shenyang, Liaoning, China.
Jin-Chi LiuDepartment of Gynecology, Liaoning Institute of birth health and development, Reproductive Hospital of China Medical University, Shenyang, Liaoning, China.
Dong-Hui HuangDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Qi-Jun WuKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, China.ORCID http://orcid.org/0000-0001-9421-5114
Ting-Ting GongDepartment of Gynecology, Liaoning Institute of birth health and development, Reproductive Hospital of China Medical University, Shenyang, Liaoning, China. gongtt@sj-hospital.org.ORCID http://orcid.org/0000-0002-3813-8932

Funding

Liaoning Province Educational Science Planning Project JG22DB707Liaoning Province Science and Technology Plan 2023JH2/20200019Liaoning Provincial Natural Science Foundation of China 2025-BS-0559National Key Research and Development Program of China 2022YFC2704205Natural Science Foundation of China 82073647Natural Science Foundation of China 82103914Scientific Research Project of Education Department of Liaoning Province LJKMZ20221137
6 · The paper itself

Abstract

purposeThe objective was first to investigate the associations between plasma levels of trimethylamine N-oxide (TMAO) and related metabolites [choline, betaine, L-carnitine, methionine, dimethylglycine (DMG)] and overall survival (OS) in patients diagnosed with high-grade serous ovarian cancer (HGSOC).

methodsA nested case-control study was conducted within the Ovarian Cancer Follow-Up Study. The study included 159 pairs of deceased and surviving patients, matched by age at diagnosis, body mass index, and sample date. The plasma levels of TMAO and related metabolites at baseline were measured using a liquid chromatography system coupled with tandem mass spectrometry. Multivariable conditional logistic regression models were employed to estimate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs).

resultsThe elevated plasma TMAO levels in the highest tertile were significantly associated with poorer OS of HGSOC in the multivariate-adjusted model (OR = 2.05, 95%CI = 1.11-3.78). Conversely, high levels of choline, betaine, methionine, and total methyl donors exhibited a positive association with improved OS of HGSOC [ORs and 95%CIs (Tertile 3 vs. Tertile 1): 0.51 (0.27-0.95), 0.49 (0.25-0.97), 0.40 (0.21-0.76), and 0.26 (0.13-0.54), respectively]. Significant dose-response relationships with OS in HGSOC were also observed for these exposures. However, no associations were observed between L-carnitine, DMG, Betaine/Choline, DMG/Choline, and DMG/Betaine with OS in HGSOC.

conclusionElevated plasma TMAO levels were associated with poor OS of HGSOC. While increased levels of choline, betaine, methionine, and total methyl donors were related to an improved OS of HGSOC.

Indexed as

MethylaminesOvarian NeoplasmsAgedBetaineCarnitineCase-Control StudiesCholineFemaleFollow-Up StudiesHumansLogistic ModelsMethionineMiddle AgedOdds RatioSarcosineBetaineCarnitineCholinedimethylglycineMethionineMethylaminesSarcosinetrimethyloxamineMicrobial metaboliteNested case-control studyOvarian cancerPrognosisTrimethylamine N-oxide

Identifiers

PMID42418014

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.