ReviewCurrent HIV/AIDS reports2026
A Leap Forward in Vaccination - the Epigenetic Silencing of HIV by cVacc.
Review in Current HIV/AIDS reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMore than four decades of HIV/AIDS studies reveal that generation of effective vaccines against HIV infection requires understanding of a host immunity that protects our DNA against the HIV infection. An effective vaccine can elicit the host immunity to stop HIV RNA expression despite the viral DNA integrated into the host DNA. RECENT
findingsVaccination is one of the most successful public health interventions of all time. Recent studies show that humans have an intrinsic immunity against foreign nucleotide gene expression, and we have named this the epigenetic immunity. We propose that chromatin vaccine (cVacc), a foreign DNA in chromatin format, is capable of triggering the immunity of host DNA, the epigenetic immunity, to silence the viral gene expression at its RNA transcription level. We discuss these advances in the field of host - virus interaction, specifically host immunity against the retroviral infections by silencing its gene expression, ranging from nucleotide sensors that distinguish self-nonself to the chromatin features that constrict the HIV reservoir. Bolstered by the progress in the fields of virology, immunology and epigenetics, we propose to maneuver cutting edge technologies to develop next-generation vaccines like cVacc, not only silencing the foreign gene expression, but assimilating it to improve our DNA function as well.
Indexed as
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42418045What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.