ArticleIrish journal of medical science2026
Downregulation of miR-3074-5p slows cervical cancer progression by targeting TGFBR2 expression.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundA growing body of evidence suggests that microRNAs (miRNAs) are key regulatory factors in cervical cancer (CC). However, the role and mechanism of action of miR-3074-5p in CC remain unclear.
objectiveThe objective of this research is to elucidate the function of miR-3074-5p in CC.
methodsTumor tissues were collected from 141 CC patients. RT-qPCR was used to detect miR-3074-5p expression. Kaplan-Meier survival curves analyzed the association between the miR-3074-5p and 5-year overall survival rates. Cox regression models evaluated the potential prognostic value of miR-3074-5p. Cell proliferation was assessed using the CCK-8 assay, while cell migration and invasion capabilities were evaluated via Transwell experiments. Dual-luciferase reporter gene assays (DLR) and RNA immunoprecipitation (RIP) experiments identified miR-3074-5p target genes, with Pearson correlation analysis evaluated their associations.
resultsmiR-3074-5p was markedly increased in CC. Its overexpression was closely associated with poor patient prognosis. Inhibiting miR-3074-5p expression effectively attenuated the malignant behavior of CC cells. miR-3074-5p directly targets TGFBR2, with inverse expression patterns confirmed in clinical samples. Rescue experiments demonstrated that TGFBR2 knockdown partially counteracted the tumor-suppressive effects induced by miR-3074-5p inhibition.
conclusionDownregulation of miR-3074-5p suppresses the malignant phenotype of CC cells by targeting TGFBR2. This finding provides initial insights into the cellular behavior of CC.
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