Evidence map›Paper›PMID 42418487›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Circulating PEG-indoleamine 2,3-dioxygenase ameliorates diverse inflammatory diseases without toxicity or compromising immunocompetence.

Jennifer A Simonovich, Ryan A Clark, Alexander J Kwiatkowski, Madeline J Fuchs, Mariana E Viso, Chen Lu, Sabrina L Macias, Isabella Pinto, Abhishek P Shrestha, Tran B Ngo and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Jennifer A SimonovichJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.ORCID 0000-0002-7731-8872
Ryan A ClarkJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.
Alexander J KwiatkowskiJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.ORCID 0000-0001-5435-3555
Madeline J FuchsJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.ORCID 0009-0000-9673-2887
Mariana E VisoJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.ORCID 0000-0002-1821-458X
Chen LuJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.
Sabrina L MaciasJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.
Isabella PintoJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.
Abhishek P ShresthaDepartment of Surgery, Division of Transplantation and Hepatobiliary Surgery, College of Medicine, University of Florida, Gainesville, FL 32610.ORCID 0000-0003-1576-8584
Tran B NgoJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.ORCID 0000-0002-4093-7004
Sergio DuarteDepartment of Surgery, Division of Transplantation and Hepatobiliary Surgery, College of Medicine, University of Florida, Gainesville, FL 32610.
Yong HeDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Qiongyao HuDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Guanyi LuDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Joseph B HartmanDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Gang SuDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Salvatore T ScaliDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Scott A BerceliDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.ORCID 0000-0003-2257-0111
Ashish K SharmaDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.ORCID 0000-0002-1234-6039
Gilbert R UpchurchDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Shamima IslamDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.ORCID 0000-0001-6946-0492
Arun WanchooJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.
Gregory A HudallaJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.ORCID 0000-0003-2259-0809
Scott T RobinsonDepartment of Surgery, Division of Vascular Surgery and Endovascular Therapy, College of Medicine, University of Florida, Gainesville, FL 32610.
Ali ZarrinparDepartment of Surgery, Division of Transplantation and Hepatobiliary Surgery, College of Medicine, University of Florida, Gainesville, FL 32610.
Dorina AvramDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.
Benjamin G KeselowskyJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL 32610.ORCID 0000-0001-6474-7769

Funding

Tissue-Anchored vs. Circulating Engineered Enzyme Constructs for Immunometabolic Resolution of PsoriasisR01AI171045 · NIAID · UNIVERSITY OF FLORIDA · PI Dorina Avram, Benjamin George Keselowsky · 2023 to 2026
$3.1M
Diversity Supplement: Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion InjuryR01DK129690 · NIDDK · UNIVERSITY OF FLORIDA · PI KESELOWSKY, BENJAMIN GEORGE, ZARRINPAR, ALI · 2022 to 2025
$2.7M
Tolerogenic dual microparticle system for treatment of multiple sclerosisR01AI133623 · NIAID · UNIVERSITY OF FLORIDA · PI AVRAM, DORINA, KESELOWSKY, BENJAMIN GEORGE · 2017 to 2021
$2.6M
Mentoring Patient-Oriented Research in Immune Response in TransplantationK24AI187634 · NIAID · UNIVERSITY OF FLORIDA · PI ALI ZARRINPAR · 2025 to 2026
$251k
Association of VA Surgeons Faculty Research Award 2022NIAID NIH HHS K24 AI187634NIAID NIH HHS R01 AI133623NIAID NIH HHS R01 AI171045NIDDK NIH HHS R01 DK129690
6 · The paper itself

Abstract

Indoleamine 2,3-dioxygenase (IDO), the enzyme responsible for tryptophan catabolism, is protective in many autoimmune and inflammatory diseases. We previously developed a localized immunomodulation approach through the fusion of IDO to a carbohydrate binding protein [E. Bracho-Sanchez

Indexed as

ImmunocompetenceIndoleamine-Pyrrole 2,3,-DioxygenaseInflammationPolyethylene GlycolsAnimalsEncephalomyelitis, Autoimmune, ExperimentalFemaleMiceMice, Inbred C57BLIndoleamine-Pyrrole 2,3,-DioxygenasePolyethylene Glycolsautoimmune diseasesenzyme therapeuticimmunotherapeuticinflammatory diseases

Identifiers

PMID42418487
PMCPMC13367878

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.