ArticleScience advances2026
Reprogramming of valine metabolism mediated by abnormally low ALDH6A1 expression promotes invasive metastasis of gastric cancer.
Jipeng Wang, Lei Han, Gang Li, Hantao Guo, Wenyue Xu, Lianghui Xia, Menghan Nie, Qing Yang, Yinghao Luo, Yaxu Wang and 4 more
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Jipeng WangDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0009-0003-6353-3525 Lei HanDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0000-0002-1752-8384 Gang LiDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0000-0002-2093-0796 Hantao GuoDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Wenyue XuDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0009-0003-9184-171X Lianghui XiaState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Menghan NieState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Qing YangState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Yinghao LuoDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Yaxu WangDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Qiuming HeDepartment of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yan-Xiao JiState Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.ORCID 0000-0002-3401-2427 Bin XiongDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0000-0003-3657-8405 Shuyi WangDepartment of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0000-0002-2597-3875 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Metastasis in gastric cancer requires metabolic reprogramming, but its key drivers remain unclear. Using a CRISPR-Cas9 metabolic knockout screen integrated with patient transcriptomes, we identified the mitochondrial enzyme ALDH6A1 as an anti-invasive factor.
Indexed as
Aldehyde DehydrogenaseGene Expression Regulation, NeoplasticStomach NeoplasmsAnimalsCell Line, TumorEpigenesis, GeneticHumansLiver NeoplasmsMetabolic ReprogrammingMiceNeoplasm InvasivenessNeoplasm MetastasisAldehyde Dehydrogenase
Identifiers
PMID42418576
PMCPMC13344286
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