Evidence mapPaperPMID 42418593Full record

ArticleScience advances2026

VCAM-1-targeting peptide assemblies protect vascular endothelium and prolong cardiac xenograft survival.

Yi-Jing Li, Hang Zhang, Zhe Sun, Kai Xing, Xiumeng Hua, Peiyuan Li, Xiao Chen, Han Mo, Jiangping Song

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi-Jing LiShenzhen State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen 518057, China.ORCID 0000-0003-0574-8520
Hang ZhangState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Zhe SunShenzhen State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen 518057, China.ORCID 0000-0002-7967-8185
Kai XingState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.ORCID 0000-0001-7087-0157
Xiumeng HuaState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.ORCID 0009-0006-5424-8812
Peiyuan LiState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Xiao ChenState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.ORCID 0009-0002-6916-3548
Han MoShenzhen State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen 518057, China.ORCID 0000-0002-5089-9638
Jiangping SongShenzhen State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen 518057, China.ORCID 0000-0002-9488-7823

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac xenotransplantation represents a promising strategy to address the shortage of donor hearts, yet endothelial cell dysfunction remains a major obstacle to long-term graft survival. Using integrated single-cell RNA sequencing in a porcine-to-primate xenotransplantation model, we identified a VCAM-1

Indexed as

Endothelium, VascularGraft SurvivalHeart TransplantationPeptidesVascular Cell Adhesion Molecule-1AnimalsEndothelial CellsHeterograftsHumansNanoparticlesSwineTransplantation, HeterologousPeptidesVascular Cell Adhesion Molecule-1

Identifiers

PMID42418593
PMCPMC13344358

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.