ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
MAM-Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic microinflammation drives tissue degeneration, particularly in age-related and metabolic diseases, yet how it disrupts inter-organelle communication that leads to cellular failure remains largely unexplored. Utilizing highly myopic cataract (HMC) as a paradigm, we uncover a non-canonical defense mechanism centered on mitochondria-associated endoplasmic reticulum membranes (MAMs). Under microinflammatory stress, mesencephalic astrocyte-derived neurotrophic factor (MANF), conventionally recognized as an ER-resident protein, specifically localizes to MAMs in lens epithelial cells (LECs). At this critical interface, MANF acts as a metabolic sensor that safeguards calcium homeostasis by directly promoting the ubiquitin-mediated degradation of the sarco/endoplasmic reticulum Ca
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