ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
Mast Cells in the Developing Brain.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Brain development requires the coordination of numerous cell types including neurons, glia, and immune cells. Mast cells (MCs) are tissue-resident innate immune cells canonically known for their role in allergic responses and anaphylaxis. In the central nervous system (CNS), MCs populate the meninges and brain parenchyma, exhibiting dynamic, age- and region-dependent changes during neurodevelopment. Emerging evidence indicates that CNS-resident MCs may influence key neurodevelopmental processes through bidirectional cross talk with microglia, regulation of blood-brain barrier permeability, and orchestration of peripheral immune cell recruitment to the developing brain. However, significant challenges exist regarding tools to precisely dissect the contribution of MCs in these processes. Clinically, MC-derived mediators including interleukin 6 and histamine have been implicated in neurodevelopmental disorder (NDD) etiology, with epidemiological links between allergic disease and elevated risk for NDD. This review synthesizes current knowledge of MC biology in the developing brain and highlights critical gaps requiring further investigation to understand their role in neurodevelopment and neurological disease susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.