Evidence map›Paper›PMID 42420462›Full record

ArticleNature2026

Diet-microbiome synergy underlies obesity-associated immunotherapy efficacy.

Lysanne Desharnais, Anikka Swaby, Meriem Messaoudene, Samuel Doré, Miranda W Yu, Benoit Fiset, Valérie Breton, Mayra Ponce, Yongjia Hu, Liam Wilson and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lysanne DesharnaisRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Anikka SwabyRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Meriem MessaoudeneResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Samuel DoréRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Miranda W YuRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-3902-0124
Benoit FisetRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-0372-8868
Valérie BretonRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Mayra PonceResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Yongjia HuResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Liam WilsonRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0009-0008-1439-6911
Mark SorinRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Ye WangLady Davis Research Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-3133-3348
Ken DewarDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Michael PollakLady Davis Research Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-3047-0604
Arielle ElkriefResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-1981-1535
Bertrand RoutyResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. bertrand.routy@umontreal.ca.ORCID http://orcid.org/0000-0003-1955-9149
Logan A WalshRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca.ORCID http://orcid.org/0000-0001-8771-2577
Daniela F QuailRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.ORCID http://orcid.org/0000-0002-6969-3250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physiological host factors, such as the gut microbiome and obesity, independently influence anti-tumour immunity and responses to immune checkpoint inhibitors (ICIs)

Identifiers

PMID42420462

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.