Evidence map›Paper›PMID 42420523›Full record

ArticleNature genetics2026

Metabolically and epigenetically reprogrammed splenic TRNP1

Liyuan Zhang, Yahui Wang, Kai Wei, Wen Nie, Yayuan Feng, Zhiwen Shi, Hongmei Xiao, Weifen Xie, Yong Lin, Xin Zeng and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Liyuan Zhang *National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.
Yahui Wang *National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.
Kai Wei *Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Wen Nie *National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.
Yayuan Feng *Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Zhiwen Shi *Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Hongmei XiaoDepartment of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Weifen XieDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yong LinDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xin ZengDepartment of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yongquan ShiDepartment of Endocrinology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Wei TangDepartment of Endocrinology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Tuo LiDepartment of Endocrinology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Fu YangNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0003-2459-3923
Ye ZhouNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0002-8780-0099
Minjun WangNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.
Yanfang LiuNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0002-2923-0729
Shanrong LiuNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.
Jin HouNational Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China. houjin@immunol.org.ORCID http://orcid.org/0000-0002-8670-517X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32400743National Natural Science Foundation of China (National Science Foundation of China) 82530060National Natural Science Foundation of China (National Science Foundation of China) 92269204
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD), especially its severe form, metabolic dysfunction-associated steatohepatitis (MASH), progresses to liver fibrosis, leading to cirrhosis and liver cancer. The cross-talk between spleen and liver in MASLD/MASH progression remains poorly understood. Here we found enlarged spleens in patients with MASLD and identified induced TRNP1

Indexed as

CD8-Positive T-LymphocytesEpigenesis, GeneticLiver CirrhosisSpleenAnimalsDisease Models, AnimalFurinHepatic Stellate CellsHumansLiverMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseFurin

Identifiers

PMID42420523
PMCPMC13447098

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.