Evidence mapPaperPMID 42420706Full record

ReviewAdvances in experimental medicine and biology2026

A Brief Overview of Biomechanics and Mechanobiology of the Pulmonary Circulation.

Abhay B Ramachandra, Edward P Manning

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In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Abhay B RamachandraDepartment of Mechanical Engineering, Iowa State University, Ames, IA, USA.
Edward P ManningVA Connecticut Healthcare System, West Haven, CT, USA. edward.manning@yale.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This chapter delves into the biomechanics and mechanobiology of the right side of the human circulatory system, focusing on the vascular pulmonary circulation driven by the right ventricle. Pulmonary circulation is necessary for oxygenating deoxygenated blood returning from the body. It plays the unique role of joining the circulatory system with the pulmonary airways. A better appreciation of biomechanics (the physical properties and behaviors of biological tissues under various forces and deformations) and mechanobiology (how cellular and molecular activities respond to their mechanical environment) enables a better understanding of cardiopulmonary physiology and pathophysiology. The anatomical and functional challenges of assessing right ventricle dynamics, the biomechanical properties of the pulmonary vasculature, and the implications of mechanobiological interactions in disease and therapy are discussed. Some examples of complex adaptations and remodeling in response to aging and disease are highlighted. The importance of mechanical testing protocols, theoretical constitutive formulations, and advanced imaging techniques in understanding these physiological processes is briefly reviewed. Attention is given to current experimental capabilities, challenges, and the integration of computational models to enhance clinical insights and therapeutic approaches.

Indexed as

LungPulmonary ArteryPulmonary CirculationAnimalsBiomechanical PhenomenaHemodynamicsHumansModels, CardiovascularVascular RemodelingBiomechanicsCardiopulmonary physiologyMechanobiologyPulmonary circulationPulmonary treeVascular remodeling

Identifiers

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.