Observational studyBMC nephrology2026
Association of systemic inflammatory response index (SIRI) with clinical outcomes in hemodialysis patients: a single-center observational study.
Observational study in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionPatients undergoing maintenance hemodialysis (MHD) carry a substantial burden of cardiovascular disease and mortality. Accessible prognostic biomarkers are needed to improve risk stratification. We examined the association between the systemic inflammatory response index (SIRI) and clinical outcomes, and compared SIRI with established inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR), as well as conventional clinical parameters such as C-reactive protein (CRP), white blood cell count, and serum albumin.
methodsA retrospective analysis was conducted in a cohort of 221 prevalent hemodialysis patients enrolled at Dongguan Tung Wah Hospital between January and July 2019. Patients were categorized into tertiles based on SIRI for baseline comparison. Associations between SIRI (modeled as a continuous variable) and the risks of cardiovascular events and all-cause mortality were assessed using Cox proportional hazards models, Kaplan-Meier survival curves, and restricted cubic spline analyses.
resultsDuring a median follow-up period of 28 months, a total of 30 MHD patients (13.6%) died from any cause, and 47 patients (21.3%) experienced cardiovascular events. Kaplan-Meier analysis revealed that higher SIRI levels were significantly associated with increased cumulative incidence of cardiovascular events and elevated all-cause mortality (both P < 0.001). After multivariable adjustment, higher SIRI values were independently associated with greater risks of cardiovascular events (adjusted hazard ratio [HR] per unit increase, 1.121; 95% confidence interval [CI], 1.041-1.206; P = 0.003) and all-cause mortality (adjusted HR, 1.18; 95% CI, 1.11-1.29; P < 0.001). In receiver operating characteristic analyses, SIRI exhibited the numerically highest AUC among the evaluated biomarkers for predicting cardiovascular events (AUC, 0.677) and all-cause mortality (AUC, 0.794). DeLong's test showed no statistically significant differences between the AUC of SIRI and those of NLR, MLR, CRP, WBC, or albumin for cardiovascular events (all P > 0.05). For all-cause mortality, SIRI showed no statistically significant differences compared with NLR (P = 0.467), MLR (P = 0.941), and CRP (P = 0.573), but was significantly superior to WBC count (P < 0.001) and albumin (P = 0.012).
conclusionElevated SIRI is independently associated with adverse outcomes in maintenance hemodialysis patients. In direct comparison with NLR, MLR, CRP, WBC count, and albumin, SIRI demonstrated comparable predictive performance for both cardiovascular events and all-cause mortality.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.