Evidence map›Paper›PMID 42420989›Full record

ArticleNutrition journal2026

Circulating metabolites in plasma reveal potential target of lung cancer prevention: insights from fatty acids pathway.

Yunyun Liu, Qinghan Liu, Tong Sun, Honghao Yang, Zheng Ma, Liuxin Li, Chao Ji, Huanhuan Chen, Yang Xia

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Article in Nutrition journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yunyun Liu *State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China.
Qinghan Liu *Department of Thoracic Surgery, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, China.
Tong SunSchool of Medicine, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058, China.
Honghao YangDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, China.
Zheng MaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, China.
Liuxin LiDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, China.
Chao JiDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, China.
Huanhuan ChenDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, China. chenhh@sj-hospital.org.
Yang XiaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang, 110004, China. xytmu507@126.com.ORCID http://orcid.org/0000-0001-8783-1592

Funding

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases zz202602The LiaoNing Revitalization Talents Program XLYC2203168
6 · The paper itself

Abstract

backgroundProspective evidence regarding the associations between circulating fatty acids (FAs) and lung cancer risk-particularly regarding their interplay with exposome factors and genetic susceptibility-remains limited. Furthermore, the predictive utility of FAs as biomarkers for lung cancer has not been fully characterized. Therefore, this study aims to evaluate the associations of circulating FAs metabolism with lung cancer risk, focusing on their interactions with smoking and genetic risk profiles, while further assessing their potential as predictive biomarkers.

methodsA total of 107,954 participants from the UK Biobank study were included in analyses. The associations of circulating FAs, as well as their interactions with polygenic risk score (PRS), smoking status, and FA-related genetic variants, with lung cancer were examined. The differential expression of genes and hub gene involved in FAs metabolism in lung cancer were explored using RNA-sequencing data from The Cancer Genome Atlas. 10-year lung cancer risk prediction models were developed and evaluated incorporating FAs, PRS, and traditional risk factors.

resultsA total of 965 lung cancer cases occurred during a mean follow-up of 12.12 years. Circulating saturated FAs (SFAs), monounsaturated FAs (MUFAs) and n-6/n-3 PUFAs ratios were positively associated with lung cancer, whereas polyunsaturated FAs (PUFAs)/n-3 PUFAs were negatively associated with the outcome (all P

conclusionOur study identifies significant associations between circulating FAs and lung cancer, characterized by interplays with smoking and genetic risk profiles. These metabolic markers provide incremental predictive value, offering new insights into risk stratification and individualized lung cancer prevention.

Indexed as

Fatty AcidsLung NeoplasmsAgedFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedProspective StudiesRisk FactorsSmokingUK BiobankUnited KingdomFatty AcidsAssociationCirculating fatty acidsLung cancerPrediction

Identifiers

PMID42420989

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.