Evidence map›Paper›PMID 42421145›Full record

ArticleTrials2026

Continuous versus intermittent lumbar CSF drainage in aneurysmal arachnoid hemorrhage: a prospective, randomized controlled trial protocol.

Kuangyang Yu, Wen Tan, Lu Jiang, Jinwei Pang, Fengwang Xue, Kunyang Bao, Changren Huang, Yong Jiang, Jianhua Peng

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kuangyang Yu *Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Wen Tan *Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Lu JiangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Jinwei PangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Fengwang XueDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Kunyang BaoDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Changren HuangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Yong JiangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China. jiangyong@swmu.edu.cn.
Jianhua PengDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China. pengjianhua@swmu.edu.cn.

Funding

Luzhou Government-Southwest Medical University Cooperation Project 2024LZXNYDJ005the National Natural Science Foundation of China 82271306the National Natural Science Foundation of China U24A20689the Sichuan Science and Technology Support Program 2024ZYD0113
6 · The paper itself

Abstract

backgroundHydrocephalus, as a common complication following aneurysmal subarachnoid hemorrhage (aSAH), not only leads to neurological dysfunction in patients but is also associated with a relatively high mortality rate.

methodsThis study is a prospective, single-center, randomized controlled trial. It is planned to recruit 256 patients with aSAH (parallel design, with a 1:1 allocation). Subjects will be assigned to the continuous lumbar drainage (LD) group and the intermittent LD group after undergoing surgical treatment (within 72 h). The primary outcome events will be defined as the degree of improvement in patients' 180 (± 7 days) modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS) scores, incidence of shunt-dependent hydrocephalus, and 30 days mortality after randomization. Recruitment will be finished by November 2027. All the patients will be followed for at least 180 (± 7 days). The trial is scheduled to complete in 2028. DISCUSSION: This study aims to explore the safety and effectiveness of different LD methods after aSAH, evaluate whether there are different impacts on the neurological prognosis of patients, and determine whether the incidence of shunt-dependent hydrocephalus varies among different methods. It is intended to provide high-quality evidence-based medical evidence for the clinical management of hydrocephalus after aSAH.

trial registrationChiCTR2500096647 with chictr.org.cn. Registered on 27 January 2025.

Indexed as

Cerebrospinal Fluid ShuntsDrainageHydrocephalusSubarachnoid HemorrhageHumansProspective StudiesRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeAneurysmal subarachnoid hemorrhageHydrocephalusLumbar drainageRandomized trial

Identifiers

PMID42421145
PMCPMC13632333

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.