ArticleJournal of clinical neurology (Seoul, Korea)2026
Diagnostic Value and Clinical Significance of Temporopolar White-Matter Hyperintensities in CADASIL and Sporadic Small-Vessel Disease.
Article in Journal of clinical neurology (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Rethinking Temporopolar White-Matter Hyperintensity in CADASIL: A Context-Dependent Biomarker.Journal of clinical neurology (Seoul, Korea) · 2026Article
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6 authors.
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Abstract
background and purposeCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by
methodsWe analyzed 385 CADASIL patients and 191 sporadic SVD patients in whom no pathogenic mutations were identified in the next-generation sequencing of 183 genes. CADASIL patients were stratified into high-, medium-, and low-risk epidermal growth factor-like repeat (HR-, MR-, and LR-EGFr) categories according to the variant locations. The severity of temporopolar WMH was scored using Scheltens' scale, and disability was assessed using the modified Rankin Scale (mRS). Logistic and ordinal regression models were used to evaluate the associations between temporopolar WMH, clinical severity, and neuroimaging markers.
resultsTemporopolar WMH were detected in 94.7%, 54.4%, and 33.3% of CADASIL patients carrying HR-, MR-, and LR-EGFr variants, respectively, compared with in 31.9% of the sporadic SVD patients. The sensitivity for distinguishing HR-EGFr carriers from sporadic SVD was high (95%), but lower for MR-EGFr (54%) and LR-EGFr (33%) carriers. In the CADASIL patients, temporopolar WMH independently predicted greater disability (mRS score >3), and they were correlated in a dose-dependent manner with the total WMH volume, Fazekas scores, and number of lacunes. Similar associations were observed in sporadic SVD.
conclusionsThe diagnostic accuracy of temporopolar WMH varies with the
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