Evidence map›Paper›PMID 42421547›Full record

ArticleActa physiologica (Oxford, England)2026

Levetiracetam inhibits the Na

Laura Øllegaard Johnsen, Lasse Messell Desdorf, Nicoline Stærke Jensen, Jeppe Praetorius, Helle Hasager Damkier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura Øllegaard JohnsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Lasse Messell DesdorfDepartment of Chemistry, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0009-0004-3290-3869
Nicoline Stærke JensenDepartment of Chemistry, Aarhus University, Aarhus, Denmark.
Jeppe PraetoriusDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-6109-247X
Helle Hasager DamkierDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-7518-4017

Funding

Aarhus Universitets ForskningsfondDanmarks Frie Forskningsfond 3101-00092BNovo Nordisk Fonden NNF18OC0052038
6 · The paper itself

Abstract

aimThe Na

methodsThe Ncbe and NBCn1 activity was assessed in heterologous expression systems as Na

resultsLevetiracetam inhibited Ncbe-mediated transport, whereas no levetiracetam-sensitive NBCn1-mediated component was detected under the same experimental conditions. In choroid plexus epithelial cells, levetiracetam reduced Na

conclusionThese findings identify Ncbe as a levetiracetam-sensitive HCO

Indexed as

Chloride-Bicarbonate AntiportersChoroid PlexusLevetiracetamSodium-Bicarbonate SymportersAnimalsHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLChloride-Bicarbonate AntiportersLevetiracetamSlc4a10 protein, mouseSodium-Bicarbonate Symporterscerebrospinal fluid secretionchoroid plexuslevetiracetamNcbeSlc4a10

Identifiers

PMID42421547
PMCPMC13347204

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.