SynthesisFrontiers in oral health2026
Effect of the multiple sutures and suture-less wound closure on the wound healing after surgical extraction of the mandibular third molars: a systematic review and metaanalysis.
Synthesis in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Surgical extraction of mandibular third molars is a common procedure performed in clinical practice yet it commonly yields postoperative pain, facial swelling, and trismus. While multiple-suture primary closure has traditionally been used, suture-less wound closure has emerged as an alternative. Aim: This systematic review and meta-analysis aimed to compare the effect of suture-less vs. multiple-suture wound closure on early postoperative pain, facial swelling, and trismus after mandibular third molar surgery. Material and methods: A comprehensive literature search was conducted in several databases for articles from January 2000 to December 2025. Only randomized controlled trials comparing suture-less and multiple-suture closure after surgical extraction of mandibular third molars were included. Meta-analyses were performed in RevMan 5.4 using a random-effects model due to substantial heterogeneity ( Results: Ten RCTs were included. Meta-analysis showed that pain at 48 h was lower in the suture-less group (mean difference: -0.46; 95% CI: -3.69, 2.77; Conclusions: Suture-less techniques may be considered a safe and reasonable alternative as both approaches were associated with comparable early postoperative outcomes to multiple-suture primary closure in terms of pain, facial swelling, and trismus. Suture-less wound closure after surgical extraction of mandibular third molars can be a valid choice particularly when the goal is to minimize early inflammatory sequelae and patient discomfort. Systematic Review Registration: PROSPERO CRD42024563350.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.