Taste receptor downregulation in diet-induced obesity reveals circumvallate papillae-specific taste-inflammatory networks.

Isabella Kimmeswenger, Andrej Feješ, Veronika Somoza, Katarína Šebeková, Barbara Lieder

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

5 authors.

Isabella Kimmeswenger *Faculty of Chemistry, Institute of Physiological Chemistry, University of Vienna, Vienna, Austria.

Andrej Feješ *Faculty of Medicine, Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia.

Veronika SomozaFaculty of Chemistry, Institute of Physiological Chemistry, University of Vienna, Vienna, Austria.

Katarína ŠebekováFaculty of Medicine, Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia.

Barbara LiederFaculty of Chemistry, Institute of Physiological Chemistry, University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Beyond their role in chemosensory perception, taste receptors function as metabolic regulators extra-orally. While decreased taste receptor expression in gustatory tissue is linked to obesity-associated inflammation, we tested the hypothesis that taste receptor-inflammation interactions extend to extra-oral contexts. Methods: Obesity-associated metabolic syndrome-like phenotype was induced in female C57BL/6 mice by administration of a cafeteria diet for 18 weeks. The controls consumed a standard diet. Gene-expression levels of Results and discussion: The cafeteria diet induced obesity, metabolic dysfunction, and systemic inflammation. Additionally, number and area of fungiform papillae were reduced, and

Indexed as

cafeteria dietextra-oral taste receptorsfungiform papillaeinflammationsweet taste receptor

Identifiers

PMID42421925

DOI10.3389/fnut.2026.1857562

PMCPMC13342050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.