ArticleInnovation (Cambridge (Mass.))2026
Generalization of negative memories drives the development of psychological distress-related behaviors.
Article in Innovation (Cambridge (Mass.)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Protocol to induce memory generalization and stress-like behaviors without memory strengthening using contextual fear conditioning in mice.STAR protocols · 2026Article
- Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
17 authors.
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Abstract
Individuals with depression and anxiety often exhibit intensified and overgeneralized negative memories. However, the causal contribution of memory features, especially the relative roles of memory strengthening versus generalization in shaping subsequent affective disturbances, remains poorly understood. Here, we developed behavioral paradigms to dissociate memory generalization from strengthening and found that negative experiences leading to memory overgeneralization, but not those enhancing memory strength alone, triggered stress-related behaviors in mice. We identified the projection from medial prefrontal cortex (mPFC) to the bed nucleus of the stria terminalis (BNST) as a key circuit linking generalized memory to stress-related phenotypes. Single-cell calcium imaging revealed a significant overlap between the BNST-projecting mPFC (mPFC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.