Evidence mapPaperPMID 42422089Full record

ArticleFrontiers in pharmacology2026

Compound 4'-O-methylbroussochalcone B attenuates LPS/ATP-induced macrophage pyroptosis in vitro through modulation of the NLRP3 inflammasome and MAPK/NF-κB pathways.

Jihee Choi, You Chul Chung, Ami Lee, Han Na Kang, Youn-Hwan Hwang

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jihee Choi *KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
You Chul Chung *Research Center for Antibody platform and Infectious Disease, Scripps Korea Antibody Institute (SKAI), Hongcheon-gun, Republic of Korea.
Ami LeeKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Han Na KangKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Youn-Hwan HwangKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The compound 4'-O-methylbroussochalcone B (4'-O-M) is a chalcone-type flavonoid isolated from Methods: J774A.1 macrophages were pretreated with graded concentrations of 4'-O-M, followed by LPS priming and ATP stimulation to activate the inflammasome. Levels of nitric oxide (NO), prostaglandin E Results: 4'-O-M markedly reduced LPS-induced inflammatory mediators, suppressing NO and PGE Conclusion: 4'-O-M mitigates macrophage inflammatory responses

Indexed as

4′-O-methylbroussochalcone Bmacrophage inflammationMAPK/NF-κB signalingmitochondrial ROSNLRP3 inflammasomepyroptosis

Identifiers

PMID42422089
PMCPMC13341802

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.