ArticleFrontiers in pharmacology2026
Compound 4'-O-methylbroussochalcone B attenuates LPS/ATP-induced macrophage pyroptosis in vitro through modulation of the NLRP3 inflammasome and MAPK/NF-κB pathways.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The compound 4'-O-methylbroussochalcone B (4'-O-M) is a chalcone-type flavonoid isolated from Methods: J774A.1 macrophages were pretreated with graded concentrations of 4'-O-M, followed by LPS priming and ATP stimulation to activate the inflammasome. Levels of nitric oxide (NO), prostaglandin E Results: 4'-O-M markedly reduced LPS-induced inflammatory mediators, suppressing NO and PGE Conclusion: 4'-O-M mitigates macrophage inflammatory responses
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