Low-intensity pulsed ultrasound stimulated hydrogel-polylactic acid composite scaffolds: a dual-cue approach for enhanced rotator cuff healing.

Lan Jiang, Yangying Duan, Yong Zhang, Dong Wang, Haitao Ran

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Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Lan JiangDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Yangying DuanDepartment of Ultrasound, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.

Yong ZhangDepartment of Ultrasound, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Dong WangDepartment of Ultrasound, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.

Haitao RanDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rotator cuff tear is a prevalent musculoskeletal condition. The complex soft-to-hard transition at the tendon-bone interface (TBI) makes the healing process more challenging than in homogeneous tissues. In this study, low-intensity pulsed ultrasound (LIPUS), a non-invasive modality for bone repair, was employed as an external stimulus in combination with tissue engineering. A composite scaffold, designated as BMP-2/bFGF@GM-PLA, was developed by incorporating a gelatin-methacryloyl (GM) hydrogel loaded with bone morphogenetic protein-2 (BMP-2) and basic fibroblast growth factor (bFGF) into polylactic acid (PLA) electrospun fibers. Under LIPUS stimulation, the BMP-2/bFGF@GM-PLA scaffold effectively promotes migration, osteogenic and tenogenic differentiation of the bone marrow mesenchymal stem cells through synergistic mechanical and chemical cues.

Indexed as

acoustic stimulationcomposite scaffoldlow-intensity pulsed ultrasoundtendon–bone interface regeneration

Identifiers

PMID42422191

DOI10.1093/rb/rbag112

PMCPMC13344843

What Socratic holds

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