Evidence map›Paper›PMID 42422225›Full record

ArticleOncology letters2026

ARID3A knockdown facilitates ferroptosis partly through modulation of the PTEN/Akt pathway in breast cancer.

Pengfei Shi, Yan Yi, Maojie Zhang, Yongjun Liu, Ming Jiang, Jiaming Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pengfei ShiDepartment of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430013, P.R. China.
Yan YiInstitute of Biomedical Engineering, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Maojie ZhangDepartment of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430013, P.R. China.
Yongjun LiuDepartment of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430013, P.R. China.
Ming JiangDepartment of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430013, P.R. China.
Jiaming ZhangDepartment of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430013, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AT-rich interaction domain 3A (ARID3A) is a tumor regulator that modifies the PTEN and Akt pathway. The present study aimed to investigate the effect of ARID3A knockdown on ferroptosis and the interaction between ARID3A and the PTEN/Akt pathway in breast cancer. Firstly, MCF-7 and MDA-MB-231 cell lines were cultured. Negative control small interfering RNA (siNC) and ARID3A small interfering RNA (siARID3A) were transfected into the cells. Subsequently, siNC, PTEN small interfering RNA (siPTEN) and siARID3A were transfected into the cells alone or in combination. Comprehensive ferroptosis-associated indices were assessed. siARID3A transfection decreased cell viability, mitochondrial membrane potential (MMP) and glutathione peroxidase 4 (GPX4) expression, but increased the levels of malondialdehyde, reactive oxygen species (ROS) and ferrous iron (Fe

Indexed as

Akt pathwayAT-rich interaction domain 3Abreast cancerferroptosisPTEN

Identifiers

PMID42422225
PMCPMC13343340

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.